Spore-forming bacterium2 studiesIn 6 products

Bacillus subtilis for dogs

Bacillus subtilis is a spore-forming bacterium that appears on six products we track without any strain code attached — a broader, more generic label claim than a named strain like DE111. Two dog studies exist for it: a 36-dog trial on acute gastroenteritis found the probiotic group's abnormal stools resolved significantly faster than placebo (1.3 days versus 2.2), and a 20-dog trial testing it alongside Bacillus coagulans for allergic dermatitis found reduced symptoms and faster wound repair versus untreated dogs.

At a glanceStudied dose (dogs)Not confirmed yetStrain-numbered on labels0 of 6

Canine studies we could find

PubMed and PMC, dogs only. Other species are listed separately below and don't count toward the badge.

2024Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogsMeasured clinical dermatitis signs, wound repair time, and immune markers; probiotic-supplemented groups showed reduced symptoms, faster wound repair, and increased serum bactericidal activity against S. aureus and E. coli versus untreated controls.RCT · n=20PMID 38501344 →
2010Effects of a probiotic intervention in acute canine gastroenteritis - a controlled clinical trialMeasured time to resolution of abnormal stools; probiotic group reached resolution significantly sooner than placebo (1.3 vs 2.2 days, P=.04).RCT · n=36PMID 20137007 →

Products on the shelf that contain it

ProductCFU / doseStrain-namedOther strains
Zesty Paws Probiotic BitesSoft chew · Shelf-stablenot split outSpecies only2No Amazon listing found
PetLab Co. Probiotic ChewsSoft chew · Shelf-stablenot split outSpecies only2See on Amazon
Four Leaf Rover ProtectPowder · Shelf-stablenot split outSpecies only2See on Amazon
Pet Honesty Probiotics Gut + Immune Health Soft ChewsSoft chew · Shelf-stablenot split outSpecies only7See on Amazon
Vet's Best Probiotic Soft Chews for DogsSoft chew · unstatednot split outSpecies only5See on Amazon
Bernie's Perfect Poop Digestive SupplementPowder · Shelf-stablenot split outSpecies only1See on Amazon

Study dose for your dog

We don't have a confirmed CFU-per-kg dose number for Bacillus subtilis from the canine trials yet -- so this calculator is intentionally disabled rather than guessing.

Common questions

Is "Bacillus subtilis" on a label the same claim as a specific strain like DE111?

No. A label that just says "Bacillus subtilis" with no strain code is a broader, weaker claim than one naming a specific identified strain.

What did the dog studies find?

A 36-dog trial on acute gastroenteritis found probiotic-treated dogs' stools returned to normal significantly faster than placebo (1.3 vs 2.2 days). A separate 20-dog trial, testing it together with Bacillus coagulans for allergic dermatitis, found reduced symptoms and faster wound healing.

What dose was used?

No studied dose is confirmed for Bacillus subtilis on its own in these trials.